Drug Uses

Acyclovir is used to treat herpes infections of the skin, lip, and genitals; herpes zoster (shingles); and chickenpox. It does not cure herpes infections but decreases pain and itching and promotes healing. Topical Acyclovir does not prevent the recurrence of sores but may decrease pain and itching if applied when the earliest symptoms first appear. Oral Acyclovir decreases the frequency and severity of recurrent sores, but it is used only by people with severe herpes infections because of possible adverse effects. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

How Taken

Treatment with Acyclovir topical should be started as soon as possible after the first appearance of symptoms (e.g. tingling, burning, blisters). Wash your hands before and after applying Acyclovir topical. Wear a glove or a finger cot or use an applicator (e.g. cotton swab) when applying Acyclovir topical to avoid spreading the virus to other body parts and to other people. Apply enough ointment to cover the lesion(s) completely. A one-half inch ribbon of ointment should cover approximately 4 square inches of surface area. Avoid getting this medication in the eyes. Acyclovir topical is usually applied every 3 hours, six times a day for seven days. Follow your doctor\'s instructions. Use Acyclovir topical for the full amount of time prescribed, even if you begin to feel better. Your symptoms may start to improve before the infection is completely treated. Lesions caused by herpes viruses should be kept as clean and dry as possible. Wearing loose clothing may help to prevent irritation of the lesions.

Chronic Acyclovir-Resistant HSV-2 Ulcer in an Immunosuppressed Patient Treated ... Archives of Dermatology Pretransplant laboratory findings included HSV-2 IgG, and he had received acyclovir for prophylaxis at the time of transplant. On posttransplant day 23, he developed graft-vs-host disease and was given prednisone, mycophenolate, and cyclosporine.

Pancrelipases, Xerese Cream Returned for Routine Monitoring Medscape January 30, 2012 — Three forms of pancrelipase and an acyclovir/hydrocortisone cream were recommended for return to routine monitoring during an abbreviated review as part of the US Food and Drug Administration (FDA) Pediatric Advisory Committee ...

The Role of Antiviral Therapy After the Resolution of Acute Herpes Simplex ... Archives of Ophthalmology 5 A prospective, placebo-controlled investigation of more than 700 study participants by the Herpetic Eye Disease Study (HEDS) Group clearly established that use of oral acyclovir was effective in the prevention of recurrent HSV epithelial and stromal ... and more »

OSN SuperSite

Woman has decreased vision, pain and photophobia in left eye OSN SuperSite The patient was admitted and started on empiric treatment with IV acyclovir, pyrimethamine, sulfadiazine, prednisone and folinic acid to prevent bone marrow suppression. She underwent an anterior chamber tap for diagnostic purposes.

Zee News

Viral level in blood main cause of HIV transmission in sexual intercourse Zee News The study included 3297 HIV-discordant couples (where one person is HIV-infected, and the other is not) in eastern and southern Africa who were enrolled in a randomized trial of acyclovir suppressive therapy. The couples had frequent follow-up to ... Study Confirms Viral Load Most Important Predictor of HIV TransmissionAIDSmeds.com HIV/AIDS Treatment News Viral load a major factor affecting risk of sexually transmitting HIVScienceBlog.com (blog) all 45 news articles »

Study: Anti-infective drug shortages affect clinical care, outcomes ModernMedicine Agents in short supply are typically parenterals, including acyclovir, ciprofloxacin, piperacillin-tazobactam, streptomycin, and sulfamethoxazole-trimethoprim. But the list of unobtainable or difficult-to-obtain agents includes ointments (erythromycin ... and more »

Sexually transmitted diseases: What is genital herpes? Times of India Treatment for genital herpes: Presently, there is no remedy for genital herpes, but antiviral medicines like Acyclovir can be given to control outbreaks and sort out the sores. Doctors will also advise you on how to prevent the sores and keep them ...

What is behind this postpartum puzzler? Journal of the American Academy of Physician Assistants These diagnoses led to prescriptions for numerous medications, including oral and systemic corticosteroids, antiviral medications (acyclovir, valacyclovir), oral and systemic antibiotics (ciprofloxacin [Cipro] and ceftriaxone [Rocephin]), ...

Isolation, vaccines effective against equine herpes virus Western Producer (subscription) The latest treatment and prevention option is the antiviral drug acyclovir, which was developed for treating human herpes infections. This drug has been given to valuable horses during an outbreak of EHM to prevent them from developing the disease. and more »

Research and Markets: Dermatology Therapeutics Market to 2017 - Alopecia ... Business Wire (press release) The herpes therapeutics has strong market for some antivirals such as Zovirax (acyclovir), Famvir (famciclovir), Zostavax (Herpes Zoster Vaccine) and Valtrex (valacyclovir). These drugs contribute for more than $1.2 billion of global herpes ... and more »

Warnings/Precautions

Before using Acyclovir topical, tell your doctor if you have any other medical conditions or if you use any other medications. Acyclovir topical is in the FDA pregnancy category C, which means that it is not known whether it will harm an unborn baby. Do not use Acyclovir topical without first talking to your doctor if you are pregnant. It is not known whether Acyclovir topical passes into breast milk. Do not use Acyclovir topical without first talking to your doctor if you are breast feeding a baby.

Missed Dose

Apply it as soon as you remember and apply further doses at your regular interval (e.g., every 3 hours) until you go to bed. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Possible Side Effects

No serious side effects are expected during treatment with Acyclovir topical. If you suspect an allergic reaction (difficulty breathing; rash; hives; itching; swelling of your lips, tongue, or face) seek emergency medical attention. Other less serious side effects may be more likely to occur. Continue to use Acyclovir topical and talk to your doctor if you experience itching, stinging, burning, or a rash. These side effects should resolve quickly. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

Storage

Store below 25oC. Do not refrigerate.

Overdose

An overdose of this medication is not likely to occur. If you suspect an overdose or ingestion of Acyclovir topical, call an emergency room or poison control left for advice.

More Information

Acyclovir Cream is contra-indicated in patients known to be hypersensitive to acyclovir or propylene glycol. Acyclovir is most effective if it is started within 48 hours of when the rash first appears. Follow the directions for using Acyclovir provided by your doctor.

Disclaimer

This drug information is for your information purposes only, it is not intended that this information covers all uses, directions, drug interactions, precautions, or adverse effects of your medication. This is only general information, and should not be relied on for any purpose. It should not be construed as containing specific instructions for any particular patient. We disclaim all responsibility for the accuracy and reliability of this information, and/or any consequences arising from the use of this information, including damage or adverse consequences to persons or property, however such damages or consequences arise. No warranty, either expressed or implied, is made in regards to this information.